Dean和他的弟弟Sam一同搭檔獵捕超自然生物，有時候他們的朋友和如同爸爸的大叔Bobby Singer也會加入獵捕行列。Dean因使用大量武器而聞名於超自然獵人界，總是穿著黑鞋、黑皮衣、黑襯衫配上黑牛仔褲，一身黑為其特徵。

Dean hunts demons, spirits and other supernatural creatures with his younger brother Sam, occasionally their friend and father figure Bobby Singer.Dean is known for handling a large number of weaponry, and his signature looks are black shoes, a dark leather jackt and dark shirts with dark blue jeans.

Sam的抓鬼兄弟檔的弟弟。是Winchester夫妻的第二個孩子，小哥哥四歲。在十九歲時，和爸爸爭吵後定下合約，拋下原本獵捕超自然生物的日子，離家就讀史丹福大學。沒想到因為父親失蹤，導致他和哥哥組成抓鬼搭檔，一路上斬妖除魔。

Sam is one of two focal characters of the series. He is the couple's second child, four years younger than his older brother Dean.At nineteen, after a heated argument with John, Sam leaves for Stanford University, thus leaving his family and their hunting crusade behind him. After his father disappeared, he and his brother becomes the ghost hunters out of his expectation and deal with the paranormal thing on the way.