故事的背景是一個的由人類和魔鬼、殭屍、吸血鬼、狼人、機器人等各種生物混居的地球，故事描述了紐約"族群融合局"的社工馬克禮萊和他周遭五花八門的生物的故事。
Ugly Americans is a half-hour animated series that takes place in an alternate universe – New York City –where creatures from horror, fantasy, and science fiction live among us as ordinary citizens. Mark Lilly, a human social worker for the Department of Immigration, helps new citizens, both human and fantastic, adapt to life in the Big Apple. When he's not helping warlocks, land-whales, vampires, and man-birds adjust to human society, Mark is trying to keep his own life in check. Unfortunately, his zombie roommate, wizard boss, and demon girlfriend can't always be relied upon for help.
