洛杉磯三個感情好得不能再好的朋友，分別是小說家Melanie（瓦萊麗柏帝內飾）、眉眼燦亮神采飛揚的Joy（珍李維斯飾）與前肥皂劇女星Victoria Chase（溫蒂瑪莉克飾），當她們飛往巴黎的班機不預期迫降在克里夫蘭，永遠改變了她們的生活！沈迷於在克里夫蘭獲得的熱烈關注，並意識到她們在克里夫蘭依舊擁有的人氣未減，她們決定留下，租了戶有位難相處管理人Elka Ostrovsky（貝蒂懷特飾）的房子。
Award winning sitcom starring comedy icons Valerie Bertinelli, Jane Leeves, Wendie Malick, and Betty White. It all starts with three best friends from Los Angeles on an ill-fated flight to Paris. When their plane is forced to land in Cleveland, the ladies find the city a welcome change from Los Angeles’ youth-obsessed culture. Suddenly, they're turning heads again. They're Hot in Cleveland! So of course they decide to stay, and when they meet Elka, played by the incomparable Betty White, the laughs just naturally follow.
Three fabulous best friends from LA – novelist Melanie (Valerie Bertinelli), eye-brow archer to the stars Joy (Jane Leeves) and former soap star Victoria Chase (Wendie Malick) find their lives changed forever when their plane, headed for Paris, makes an unexpected landing – in Cleveland. Enthralled by the attention they receive and realizing they are Hot in Cleveland, they decide to stay, renting a house that comes with a very feisty caretaker, Elka Ostrovsky (Betty White).