Randy “ Mouch “ Mcholland
在本劇飾演Randy "Mouch" McHolland，一位會為了保護同事還有局裡最愛的沙發而不惜付出代價的資深消防員。
Christian Stolte stars as Randy "Mouch" McHolland, an experienced veteran who will do anything to protect his fellow firefighters - and his coveted spot on the firehouse couch.
Brian “ Otis “ Zvonecek
飾演本劇的Brian "Otis" Zvonecek,，五十一分局的雲梯救難員，有自己的podcast，分享自己的消防員智慧，受到聽眾喜愛。
Yuri Sardarov stars as Brian "Otis" Zvonecek, Firehouse 51's elevator rescue specialist who also runs a popular podcast where he shares his unique firefighter wisdom.
Joe Cruz
飾演Joe Cruz，出身芝加哥街頭，決定投入自己生命奉獻給分局，跟勇敢的同仁們一起出任務。
Joe Minoso stars as Joe Cruz, a product of Chicago's tough streets who has dedicated his life to serving with the brave men and women of the CFD.
Christopher Herrmann
飾演本劇的Christopher Herrmann，一位資歷豐富的消防員，是以家庭為重的男子。
David Eigenberg stars as Christopher Herrmann, a seasoned firefighter and salt-of-the-earth family man.
Chief Wallace Boden
飾演Battalion Chief Wallace Boden，是分局裡的指揮官，他必須處理一些重大個人抉擇。
Eamonn Walker stars as Battalion Chief Wallace Boden, a fireman's fireman who is confronted by important personal decisions.
Leslie Shay
在本劇飾演Leslie Shay，一位有專業技術，認真付出的救難醫療人員，和同事Gabriela一起在危急現場搶救傷者。
Lauren German stars as Leslie Shay, the skilled, dedicated paramedic who, along with her partner, faces harrowing situations.
Gabriela Dawson
飾演Gabriella Dawson，一位思緒敏捷，勇敢的救難醫療人員，總是和同事Leslie一起身處緊急危難的現場，和死神拔河，拯救傷者。
Monica Raymund stars as Gabriella Dawson, the fast-thinking, fearless paramedic who, along with her partner, faces harrowing situations.
Peter Mills
在本劇中飾演Peter Mills，一位年輕，剛從學校畢業的消防隊員，來到這分局跟不同年齡層的隊員一起出任務。
Charlie Barnett stars as Peter Mills, a young new academy graduate who follows a long line of multi-generational firefighters.
Matthew Casey
Jesse Spencer在本劇飾演Matthew Casey。一位強壯，仰賴直覺的消防車隊長。依舊陷在失去隊友的悲痛自責情結和得面對處理自身的感情問題。
Jesse Spencer stars as Matthew Casey, a strong, intuitive lieutenant who is still coming to grips with the loss of one of his men and grappling with relationship problems.
Kelly Severide
Taylor Kinney飾演Kelly Severide,一位性急的救難分隊隊長，常在災難現場臨危不亂指揮任務。
Taylor Kinney stars as Kelly Severide, a brash lieutenant who runs the Rescue Squad with an unflappable veneer.